Adult HTN & angina Initially 5 mg, may be increased to max dose of 10 mg depending on response. Childn 6-17 yr HTN Initially 2.5 mg once daily, up-titrated to 5 mg once daily if BP goal is not achieved after 4 wk.
Hypersensitivity to amlodipine or dihydropyridine derivatives. Severe hypotension; shock (including cardiogenic shock); obstruction of the outflow tract of left ventricle eg, high grade aortic stenosis; haemodynamically unstable heart failure after acute MI.
Exposure may be increased w/ strong or moderate CYP3A4 inhibitors eg, PIs, azole antifungals, macrolides (eg, erythromycin or clarithromycin), verapamil or diltiazem. Plasma conc may be lowered w/ CYP3A4 inducers eg, rifampicin, Hypericum perforatum. Bioavailability may be increased w/ grapefruit or grapefruit juice. Risk of hyperkalaemia w/ verapamil & IV dantrolene. Additive BP-lowering effects to other medicinal products w/ antihypertensive properties. Risk of increased tacrolimus blood levels. Increased risk of hypotension w/ clarithromycin. Increased exposure to simvastatin.
C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
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